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DeCS
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Descriptor English:
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Aflatoxin M1
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Descriptor Spanish:
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Aflatoxina M1
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Descriptor Portuguese:
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Aflatoxina M1
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Synonyms English:
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4 Hydroxyaflatoxin B1
4-Hydroxyaflatoxin B1
Aflatoxin M
Aflatoxin M1, cis(+-)-Isomer
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Tree Number:
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D03.383.663.283.119.100
D03.633.100.150.119.100
D23.946.587.142.100
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Definition English:
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A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969). |
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Indexing Annotation English:
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/antag permitted but consider also ANTITOXINS; DF: AFM1
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Pharmacological Action:
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Poisons
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History Note English:
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92; was AFLATOXIN (NM) 1980-91
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Allowable Qualifiers English:
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Record Number:
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30276
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Unique Identifier:
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D016607
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Occurrence in VHL:
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Similar:
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DeCS
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